MICRO-ultrasound Guided Prostate SBRT

Official record

Identifier

NCT07737457

Recruiting locations

country

Canada

Interventions studied

Stereotactic Body Radiation TherapyStereotactic Body Radiation TherapyExactVu

Lead sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Target enrolment

112 participants

Study type

INTERVENTIONAL

Phase

Not applicable

Status

Not yet recruiting

First posted

Jul 30, 2026

Last updated on the registry

Jul 30, 2026

Age

18 Years

Sex

MALE

Study contact

The official record lists a study contact. Contact details are published there and are intentionally not copied to this page.

Eligibility criteria

Reproduced verbatim from the official record. Eligibility is decided by the study team, never by this page.

Inclusion Criteria:

* Histologically confirmed carcinoma of the prostate (biopsy results with 12 months of enrollment)
* Intermediate risk as defined by NCCN criteria
* Conventional imaging (bone scan and abdominal pelvic computed tomography) is mandatory for NCCN unfavourable intermediate risk prostate cancer patients with PSA \> 10. Negative nodal, skeletal or visceral metastases within 16 weeks of enrollment (for patients requiring staging). Alternatively, patients with no signs of extra-prostatic disease on PSMA-PET scans are also candidates for this trial
* ECOG performance status 0-1
* Willing to give informed consent to participate in this clinical trial
* Able and willing to complete QOL questionnaires Most responsive physician definition if androgen deprivation therapy will be used (only allowed for NCCN unfavourable intermediate risk prostate cancer)

Exclusion Criteria:

* Estimated prostate volume \> 60cc (volume based on transrectal ultrasound)
* Prior TURP
* Prior prostate cancer treatment, including 5-alpha reductase inhibitor treatment
* Low, high or very high-risk disease as per NCCN guidelines
* Connective tissue disease or inflammatory bowel disease
* Contraindication to prostate microUS
* Men with double hip prostheses
* Contraindication for MRI (i.e. non-compatible stent, pacemaker, prosthesis etc.)
* Anticoagulation medication (if unsafe to discontinue for fiducial marker insertion)
* Diagnosis of bleeding diathesis