Tissue Adhesive Glue Modified Cyanoacrylate (Glubran® 2) in Soft Pancreas

Official record

Identifier

NCT07155525

Recruiting locations

country

Egypt

Interventions studied

Pancreaticojejunostomy with Modified N-Butyl-2-Cyanoacrylate (Glubran® 2)Standard(duct-to-mucosa) Pancreaticojejunostomy

Lead sponsor

Minia University

Target enrolment

194 participants

Study type

INTERVENTIONAL

Phase

Not applicable

Status

Recruiting

First posted

Sep 4, 2025

Last updated on the registry

Oct 1, 2026

Age

18 Years – 75 Years

Sex

ALL

Study contact

The official record lists a study contact. Contact details are published there and are intentionally not copied to this page.

Eligibility criteria

Reproduced verbatim from the official record. Eligibility is decided by the study team, never by this page.

Inclusion Criteria:

* Patients scheduled for elective pancreaticoduodenectomy for malignant lesions.
* Intraoperative confirmation of soft pancreatic texture (by surgeon palpation; friable, non-fibrotic pancreas).
* Age 18-75 years .
* Eastern Cooperative Oncology Group (ECOG) performance status 0-2.
* Adequate organ function defined as:

Hemoglobin ≥ 9.0 g/dL Absolute neutrophil count ≥ 1,500/μL Platelet count ≥ 100,000/μL Total bilirubin ≤ 3 times upper limit of normal Alanine transaminase (ALT) /Alanine transaminase (ALT)( ≤ 5 times upper limit of normal Serum creatinine ≤ 1.5 times upper limit of normal

* Informed consent provided.
* Willingness to comply with study procedures and follow-up requirements.

Exclusion Criteria:

* Hard pancreatic texture (intraoperative surgeon assessment).
* Emergency surgery.
* Previous pancreatic surgery or pancreatic anastomosis.
* Intraoperative identification of unresectable disease
* Known allergy to cyanoacrylate or components.
* Pregnancy or lactation.
* Active infection or sepsis.
* Inability to comply with follow-up.

Indexed under

Pancreatic Cancer