A Clinical Trial of B019 Injection in Patients With Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma.

Official record

Identifier

NCT06970496

Recruiting locations

country

China

Interventions studied

B019

Lead sponsor

Shanghai Pharmaceutical Group Biological Therapy Technology Co., Ltd.

Target enrolment

48 participants

Study type

INTERVENTIONAL

Phase

Phase 1

Status

Not yet recruiting

First posted

May 14, 2025

Last updated on the registry

Aug 14, 2026

Age

18 Years – 70 Years

Sex

ALL

Study contact

The official record lists a study contact. Contact details are published there and are intentionally not copied to this page.

Eligibility criteria

Reproduced verbatim from the official record. Eligibility is decided by the study team, never by this page.

Inclusion Criteria:

1. Subjects who can fully understand this trial and voluntarily sign the informed consent form (ICF) before any research-related procedures;
2. Histologically confirmed B-cell non-Hodgkin's lymphoma (B-NHL) with specified pathological subtypes;
3. Histologically confirmed CD19 and/or CD22 positivity;
4. Expected survival time exceeding 12 weeks;
5. ECOG performance status 0-1 (Ia) or 0-2 (Ib);
6. At least one measurable lesion in two dimensions according to the Lugano 2014 criteria;
7. Bone marrow, liver, kidney, and cardiac-pulmonary functions meeting the specified requirements; 8 Subjects who were evaluated by the researchers as tolerant to the collection of peripheral blood mononuclear cells (PBMC); 9 Subjects who were evaluated by the researchers as having no contraindications for lymphodepleting chemotherapy.

Exclusion Criteria:

1. Primary central nervous system (CNS) lymphoma; However, secondary CNS lymphoma without clinical symptoms can be enrolled after being determined by the researchers；
2. Use of the prescribed drugs or treatments within the specified time before the collection of PBMC;
3. Prior allogeneic hematopoietic stem cell transplantation;
4. Systemic intravenous infusion treatment or uncontrollable bacterial, fungal or viral infection within 2 weeks before signing the ICF;
5. A history of deep vein thrombosis or pulmonary embolism or anticoagulant therapy within 6 months before signing the ICF;
6. A clinically significant history of severe heart disease within 6 months before signing the ICF;
7. Terminal organ damage or autoimmune diseases requiring systemic immunosuppressive/systemic treatments within 2 years before signing the ICF; Or have graft-versus-host disease;
8. Prescribed malignant tumors within 5 years before signing the ICF;
9. Intestinal obstruction caused by tumor compression or vascular compression requiring emergency treatment; gastrointestinal involvement with a risk of bleeding assessed by the researchers;
10. Clinically significant CNS diseases in the past or at the time of screening;
11. A history of severe allergic reactions to the drugs or excipients that were definitely needed in this study. Or have a history of allergic reactions to tocilizumab;
12. Any indwelling tubes or drainage tubes in the bodies, the use of dedicated central venous access catheters is permitted;
13. Pregnant or breastfeeding women; or male or female subjects who are unwilling to use contraception from the time of signing the ICF until 1 year after receiving B019 injection cell infusion or until CAR is detectable in peripheral blood.;
14. The subjects who have participated in other clinical studies within the past 1 month, or whose last medication use for the last clinical study is still within the 5 half-life periods of the current drug at the time of screening;
15. Other circumstances that the researchers consider unsuitable for participating in this study.

Indexed under

Lymphoma